SERTRALINE 100MG  (100 CAPSULES)

Generic Name: sertraline
Brand Name: Zoloft
Drug class: Selective serotonin reuptake inhibitors

WHAT IS THE DOSAGE OF THIS MEDICATION?

Zoloft and its generic sertraline is available in the strength of 25mg, 50mg, and 100mg capsules.

WHAT IS THIS MEDICATION USED FOR?

Sertraline belongs to a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, panic disorder, and obsessive-compulsive disorder (OCD). Sertraline works by affecting the balance of chemicals in the brain. Specifically, it increases the level of a neurotransmitter called serotonin in the brain. Increased serotonin levels can help improve mood, reduce panic attacks, and treat OCD.

Although improvements may occur earlier, the full response to the medication may not appear until after 4 weeks of treatment or longer.

For depression and obsessive-compulsive disorder, the recommended doses range from 50 mg to 200 mg once daily, taken with food.

For panic disorder, the recommended doses range from 25 mg to 200 mg once daily.

Your doctor may start you on a lower dose and gradually increase your dose to one that's appropriate for you.

Sertraline should be taken with food, preferably in the evening. But if you prefer to take it in the morning, take it with breakfast. Swallow the capsule whole. Do not crush, chew, or divide the capsules.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not take this medication if you:

• are allergic to sertraline or any ingredients of the medication

• are taking a MAO inhibitor (e.g., phenelzine, tranylcypromine, moclobemide) or have taken a MAO inhibitor within the last 14 days

• are taking pimozide

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POTENTIAL INTERACTION WITH OTHER MEDICATION

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

The following medications could potentially interact with this medication:

• acetylsalicylic acid (ASA)

• alcohol

• amiodarone

• amphetamines (e.g., dextroamphetamine, lisdexamfetamine)

• antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)

• antipsychotic medications (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, pimozide, quetiapine, risperidone)

• apalutamide

• apixaban

• barbiturates (e.g., butalbital, pentobarbital, phenobarbital)

• benzodiazepines (e.g., alprazolam, diazepam, lorazepam)

• beta-blockers (e.g. pindolol, propranolol, sotalol)

• bromocriptine

• bupropion

• buspirone

• celecoxib

• chloral hydrate

• chloroquine

• clopidogrel

• dabigatran

• degarelix

• desmopressin

• dexmethylphenidate

• dextromethorphan

• diabetes medications (e.g., chlorpropamide, glyburide, insulin, metformin, rosiglitazone)

• dipyridamole

• disopyramide

• disulfiram

• dofetilide

• domperidone

• dronedarone

• edoxaban

• efavirenz

• enzalutamide

• ergot alkaloids (e.g., ergotamine, dihydroergotamine)

• flecainide

• glucosamine

• grapefruit juice

• heparin

• linezolid

• lithium

• low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)

• macrolide antibiotics (e.g., clarithromycin, erythromycin)

• methadone

• methylene blue

• methamphetamine

• metoclopramide

• mifepristone

• mirtazapine

• monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, rasagiline, selegiline, tranylcypromine)

• multivitamins

• muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)

• narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)

• non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)

• obinutuzumab

• octreotide

• omega-3 fatty acids

• pentoxifylline

• prasugrel

• procainamide

• quinidine

• quinine

• quinolone antibiotics (e.g., ciprofloxacin, ofloxacin, sparfloxacin)

• rifabutin

• rifampin

• rivaroxaban

• St. John's wort

• scopolamine

• seizure medications (e.g., carbamazepine, clobazam, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)

• serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron)

• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)

• other selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)

• sotalol

• tapentadol

• tetrabenazine

• thiazide diuretics (water pills; e.g., hydrochlorothiazide, indapamide, metolazone)

• thyroid replacements (e.g., desiccated thyroid, levothyroxine)

• ticagrelor

• ticlopidine

• tizanidine

• tramadol

• trazodone

• tricyclic antidepressants (e.g., amitriptyline, imipramine, nortriptyline)

• "triptan" migraine medications (e.g., eletriptan, sumatriptan)

• tryptophan

• tyrosine kinase inhibitors (e.g., dasatinib, lapatinib, nilotinib, pazopanib, sunitinib)

• vitamin E

• warfarin

• zolpidem

• zopiclone

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

This is not a complete list of possible side effects. If you notice other effects not listed, please contact your doctor or pharmacist.

Possible side effects include:

• behaviour changes (e.g., anger, anxiety, violent thoughts)

• changes in vision, including blurred vision or eye pain

• fast talking and excited feelings or actions that are out of control

• inability to sit still

• liver problems (yellowing of the eyes or skin, abdominal pain, nausea, vomiting, dark urine)

• low blood sodium (e.g., tiredness, weakness, and confusion combined with achy, stiff, or uncoordinated muscles)

• symptoms of low blood sugar (weakness, hunger, sweating, anxiety, numbness/tingling in arms/legs)

• paranoia (suspicions of people, organizations, or situations, with no basis in reality)

• restlessness

• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)

• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

• symptoms of mania (e.g., decreased need for sleep, elevated or irritable mood, racing thoughts)

• unusual or sudden body or facial movements or postures

• decreased sexual desire or ability

• diarrhea

• dizziness

• drowsiness

• dry mouth

• headache

• loss of appetite

• nausea

• nervousness

• sleep disturbance

• tremor (shakiness)

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