HUMULIN N   (10 ML)

Generic Name: insulin NPH (insulin isophane)
Brand Name: Humulin N
Drug Class: Insulin

Humulin N is available in three formats:

• 10 mL vial. Each mL contains 100 units of NPH insulin.

• Penfill Cartridge. Each mL contains 100 units of NPH insulin.

• KwikPen. Each mL contains 100 units of NPH insulin.

Insulin is a naturally occurring hormone made by the pancreas that helps our body use or store the glucose (sugar) it gets from food. For people with diabetes, either the pancreas does not make enough insulin to meet the body's requirements, or the body cannot properly use the insulin that is made. As a result, glucose cannot be used or stored properly and accumulates in the bloodstream. Insulin injected under the skin helps to lower blood glucose levels.

There are many different types of insulin and they are absorbed at different rates and work for varying periods of time. NPH is an intermediate-acting insulin. It takes 1 to 3 hours to begin working after injection, reaches its maximum effect between 5 and 8 hours, and stops working after about 18 to 24 hours.

Your required dose of insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use the insulin. Your doctor or diabetes educator will determine the appropriate dose according to various lifestyle issues and the blood glucose values obtained while monitoring your blood glucose.

Your dose of insulin should be injected subcutaneously (under the skin) to the stomach, upper arm, or thigh regions, exactly as instructed by your doctor or diabetes educator. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not inject insulin NPH into the vein and do not use insulin NPH in insulin infusion pumps. The dose of insulin is measured in international units (IU). Each mL of insulin contains 100 IU. NPH insulin is often injected once or twice daily. Your dose may differ from this. In addition to NPH insulin, doses of fast-acting insulin are usually used to control the impact of food intake on blood sugar levels during the day. There are many variations of insulin dosing.

Mix NPH insulin by slowly rolling the vial between your hands. The mixture should be uniformly white and cloudy. Do not use the insulin if it looks lumpy or grainy, seems unusually thick, sticks to the bottle or vial, or appears discoloured. Do not use the insulin if it contains crystals, if the bottle or vial looks frosted, or if the suspension remains clear after being rolled between your hands.

Keep unopened bottles of insulin in the refrigerator until needed. They may be used until the expiry date on the label. Never allow insulin to freeze. Insulin that is currently in use may be kept at room temperature for no more than 28 days and then discarded. Insulin must not be exposed to extremely hot temperatures or to sunlight. Keep insulin out of reach of children.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are using the medication without consulting your doctor.

It is very important to use this medication exactly as prescribed by your doctor. The timing of insulin with respect to your meals is crucial to keeping blood glucose under control and preventing unwanted side effects. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

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