FIASP  (10 ML)

Generic Name: insulin aspart (fast-acting)
Brand Name: Fiasp
Drug Class: Insulin

Fiasp is available in three formats:

• 10 mL vial. Each 1 mL of solution contains 100 Units of insulin aspart (equivalent to 3.5 mg).

• Penfill Cartridge. Each 1 mL of solution contains 100 Units of insulin aspart (equivalent to 3.5 mg).

• FlexTouch Pre-Filled Insulin Pen. Each 1 mL of solution contains 100 Units of insulin aspart (equivalent to 3.5 mg).

Insulin aspart is a rapid-acting mealtime insulin. When it is injected subcutaneously (under the skin), insulin helps to lower blood glucose levels. It is used along with an intermediate or long-acting insulin to lower blood glucose levels for adults and children 2 years of age and older, with type 1 diabetes. It may also be used with other insulins and metformin to treat adults with type 2 diabetes. Insulin aspart may be used to continuously deliver insulin subcutaneously, using certain insulin pumps.

There are many different types of insulin and they are absorbed at different rates and work for varying periods of time. Insulin aspart starts working within 20 minutes after the injection, has its maximum effect between 1 hour and 3 hours, and stops working after 3 to 5 hours.

Your required dose of insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use the insulin. Your doctor or diabetes educator will determine the appropriate dose for you according to various lifestyle factors and the blood glucose values obtained while monitoring your blood glucose.

Your dose of insulin should be injected subcutaneously (under the skin) to the stomach, upper arm, or thigh regions, exactly as instructed by your doctor or diabetes educator. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. The dose of insulin is measured in international units (IU). Each 1 mL of insulin contains 100 IU. Insulin aspart is injected under the skin up to 2 minutes before the start of a meal. When necessary, insulin aspart may be injected up to 20 minutes after starting a meal. Longer-acting insulins are often used along with insulin aspart to cover the periods of time between doses of insulin aspart. There are many variations of insulin dosing

Insulin aspart should be clear and colourless. Do not use the insulin if you notice anything unusual in the appearance of the solution, such as cloudiness, discoloration, or clumping.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is very important that you use this medication exactly as prescribed by your doctor. The timing of insulin with respect to your meals is crucial to keeping blood glucose under control and preventing unwanted side effects. If you miss a dose, check your blood glucose to determine whether a dose is needed. If necessary, insulin aspart may be used up to 20 minutes after starting a meal. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Keep unopened bottles of insulin in the refrigerator until needed. They may be used until the expiry date on the label. Never allow insulin to freeze. Insulin that is currently in use may be kept at room temperature for no more than 28 days and then discarded. Insulin must not be exposed to extremely hot temperatures and it needs to be protected from light. Keep insulin out of reach of children.

Do not use Fiasp if you:

• are allergic to insulin aspart or any ingredients of the medication

• are experiencing an episode of hypoglycemia (low blood sugar)

The following medications could potentially interact with Fiasp:

• acetylsalicylic acid (ASA)

• American ginseng

• androgens (e.g., testosterone)

• atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)

• beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)

• ceritinib

• chloroquine

• clarithromycin

• corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)

• danazol

• disopyramide

• epinephrine

• estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)

• garlic

• ginger

• glucagon

• goserelin

• hepatitis C antivirals (e.g., daclatasvir, ledipasvir, paritaprevir, sofosbuvir)

• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)

• hydroxychloroquine

• lanreotide

• leuprolide

• loop diuretics (e.g., bumetanide, furosemide)

• mifepristone

• monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)

• niacin

• nilotinib

• octreotide

• other diabetes medications (e.g., acarbose, canagliflozin, dapagliflozin, glyburide, linagliptin, liraglutide, metformin, pioglitazone, rosiglitazone, sitagliptin)

• pasireotide

• progestins (e.g., dienogest, levonorgestrel, medroxyprogesterone, norethindrone)

• quinine

• quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)

• selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)

• sirolimus

• somatostatin

• sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)

• sunitinib

• tacrolimus

• tramadol

• thiazide diuretics (water pills; e.g., hydrochlorothiazide, indapamide, metolazone)

• vorinostat

Possible side effects include:

• redness, itching, or swelling at the site of the injection

• changes under the skin at the injection site

• signs of low potassium levels in the blood (e.g., weakness, fatigue, muscle cramps, irregular heartbeat)

• symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness)

• skin rash

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