BUPROPION SR 150MG (90 TABLETS)

Generic Name: bupropion
Brand Name: Wellbutrin SR
Drug class: Antidepressants

WHAT IS THE DOSAGE OF THIS MEDICATION?

Wellbutrin SR and its generic bupropion SR (sustained release) is available in the strengths of 100 mg and 150 mg tablets.

WHAT IS THIS MEDICATION USED FOR?

Bupropion belongs to the family of medications known as antidepressants. It is used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD; episodes of depression that occur at the same time each year).

Bupropion works by affecting the balance of noradrenaline and dopamine, chemicals that occur naturally in the brain and affect mood. This medication is a norepinephrine and dopamine reuptake inhibitor as it binds to the sites on the norepinephrine transporter (NET) and the dopamine transporter (DAT) blocking the reuptake of the neurotransmitters norepinephrine and dopamine, respectively, from the synaptic cleft of serotonergic neurons. This may improve your energy levels, mood, appetite, sensation of anxiety/nervousness, and eventually overall general quality of life.

For the treatment of depression, the full effects of the medication may not be seen until after several weeks of treatment.

The usual recommended dose is 100 mg to 150 mg once daily. In some cases, doses of up to 300 mg per day may be used. Daily doses over 150 mg are divided into two doses. Do not exceed the maximum dose of 300 mg per day, and do not take a single dose greater than 150 mg.

Multiple daily doses should be taken at least 8 hours apart. It is very important that bupropion tablets be swallowed whole and not chewed, broken, or crushed.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose of this medication, skip the missed dose and carry on with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

WHO SHOULD NOT TAKE THIS MEDICATION

Do not take bupropion sustained release if you:

• are allergic to bupropion or to any of the ingredients of the medication

• are currently taking thioridazine (an antipsychotic medication) or have taken it in the past 2 weeks

• are having abrupt withdrawal issues from alcohol, benzodiazepines (e.g., diazepam, clonazepam, lorazepam), or other sedatives (e.g., phenobarbital)

• are taking another medication that contains bupropion (e.g., Zyban® or Wellbutrin® XL)

• have a seizure disorder or a history of seizures

• have or have had an eating disorder (bulimia or anorexia nervosa)

• have taken a monoamine oxidase inhibitor (MAO inhibitor; e.g., phenelzine, tranylcypromine) within the past 2 weeks

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POTENTIAL INTERACTION WITH OTHER MEDICATION

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

The following medications could potentially interact with bupropion sustained release:

• alcohol

• amphetamines (e.g., amphetamine, dextroamphetamine, lisdexamfetamine)

• antihistamines (e.g., doxylamine, diphenhydramine, hydroxyzine)

• anti-malarial medications (e.g., chloroquine, mefloquine, primaquine)

• anti-Parkinson medications (e.g., amantadine, apomorphine, bromocriptine, levodopa, pramipexole, ropinirole) – dopamine agonists

• antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, risperidone)

• atomoxetine

• beta-blockers (e.g., metoprolol, propranolol, timolol)

• caffeine

• carbamazepine

• clopidogrel

• codeine

• cyclophosphamide

• dabrafenib

• dexmethylphenidate

• dextromethorphan

• digoxin

• doxorubicin

• duloxetine

• efavirenz

• eliglustat

• fesoterodine

• flecainide

• galantamine

• gefitinib

• hydrocodone

• linezolid

• lithium

• lumacaftor and ivacaftor

• meperidine

• methylphenidate

• metoclopramide

• mexiletine

• mifepristone

• mirtazapine

• monoamine oxidase inhibitors (MAOI; e.g., phenelzine, tranylcypromine, moclobemide, rasagiline, selegiline) – bupropion should not be started until at least 14 days after MAO inhibitors are stopped

• nelfinavir

• nicotine replacement therapy (e.g., nicotine patch)

• phenobarbital

• phenytoin

• primidone

• promethazine

• propafenone

• rifampin

• ritonavir

• selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, escitalopram, fluoxetine, paroxetine, sertraline)

• tamoxifen

• tamsulosin

• tetrabenazine

• theophylline

• ticlopidine

• tolterodine

• tramadol

• tricyclic antidepressants (e.g., nortriptyline, imipramine, desipramine)

• venlafaxine

• vilazodone

WHAT ARE THE SIDE EFFECTS OF THIS MEDICATION?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Inform your doctor about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

This is not a complete list of possible side effects. If you notice other effects not listed, please contact your doctor or pharmacist.

Possible side effects include:

• appetite changes

• bloating

• constipation

• dizziness

• dryness of mouth

• headache

• migraine

• nausea or vomiting

• trouble sleeping

• weight changes

• aggression

• agitation

• anxiety

• confusion  

• false beliefs that cannot be changed by facts

• hallucinations (seeing, hearing, or feeling things that are not actually there)

• inability to urinate

• increased blood pressure

• low sodium levels in the blood (e.g., tiredness; weakness; confusion; with achy, stiff, or uncoordinated muscles)

• new or worsened emotional or behavioural problems

• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, skin itching, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)

• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

• skin rash, hives or itching

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